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Conversely, while ADRB functional IgG activity was highly correlated with clinical outcome here (especially for Dielmo and for the youngest children in Ndiop), anti-merozoite IgG levels (ELISA) were not when age was also considered, showing that ADRB functionality was a more relevant predictor of clinical outcome.
Combining all age groups, inflammation was a more relevant predictor than gender (Figs. 3a,b).
Furthermore, if there is a causal relationship between PFOA and uric acid, we may have misclassified PFOA by using current levels, because past levels may be the more relevant predictor.
However, given that breast cancer is believed to be initiated in the stromal or epithelial cells, it is plausible that the total quantity of target tissue is a more relevant predictor of breast cancer risk than the proportional density.
Regarding alcohol drinking, we found that the intensity (i.e. the average daily alcohol intake in grams of pure ethanol) was a more relevant predictor of risk than the duration of the habit.
Our finding of an inverse association between hypertension and dementia might be explained by the importance of age at hypertension exposure: midlife blood pressure is eventually the more relevant predictor of dementia development compared with hypertension in later life [ 28, 31].
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A selection of the more relevant predictors of in-ICU mortality is given in Fig. 2.
However, the two novel CD-associated NOD2 variants could not be identified as independent variables for the need for surgery in CD patients after logistic regression analysis, suggesting that ileal disease localization and a stricturing or penetrating phenotype are clinically more relevant predictors for the need for CD-related surgery than the NOD2 genotypes alone.
As other studies have also demonstrated [ 13, 19- 21], psychological symptoms and gender were shown to be more relevant predictors of help-seeking than personality characteristics [ 32].
Although direct comparative data are not available, we regard our findings obtained on primary specimens as more relevant predictors for clinical outcome than the observations made on cell lines.
While we also recognise that torsion stability or combined mechanisms may arguably be more clinically relevant predictors of stability, the magnitude of pull-out forces in our series (between 0.7 kN and 1.6 kN) is comparable to the range of failure values reported in the literature (0.7 kN to 2 kN).
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