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A summary of the more relevant genes detected is shown in Table S2.
Although dozens of genes have been found related to gastric cancer, they are insufficient to elucidate the tumorigenesis of GC unless more relevant genes being uncovered.
Our hypothesis is that by using samples located only on support vectors, we have a higher probability of identifying more relevant genes.
Based on the publically available datasets, this study presented a statistically robust gene-based association analysis, focusing on finding more relevant genes for BP.
These controversial results suggest that expression changes of maspin are rather secondary effects caused by similar changes to adjacent and more relevant genes, further supported by a recent study [ 48].
Although the better studied genes are more likely to have high quality annotations, less well characterized yet more relevant genes can be overlooked simply because information available about them is incomplete.
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By capturing the sequentiality as well as the locality of changes, our integrated model provides better noise reduction, and achieves more relevant gene retrieval and more accurate classification than existing methods.
Thus PcG-mediated gene regulation in stem cells could be more relevant for genes involved in development and differentiation than for pluripotent genes.
All three sampling strategies, i.e. uniform sampling, sampling less relevant negative genes with higher probabilities, and sampling more relevant negative genes with higher probabilities yielded similar AUC scores but the third strategy was significantly faster than the first and second ones as it required fewer training iterations.
Among them, the sub-category of genes coding for ribosomal proteins was the more relevant (31 genes; p-value: 2.69e-15).
We further constructed the gene networks by putting them into PubGene (www.pubgene.org), not only to examine their relationships, but also to select more relevant candidate genes.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com