A more clinically relevant end point is diabetes-specific retinopathy (moderate or more severe levels of retinopathy) that is invariably attributed to hyperglycemia.
SSEs include symptomatic pathologic fractures but not asymptomatic, radiographically identified fractures, and it has therefore been argued that SSEs may be a more clinically relevant end point.
The two different primary end points in the individual studies were chosen to address both the more clinically relevant end point of upper GI ulcers (gastric and/or duodenal) and the traditional US FDA Food and Drug Administrationn) end point of gastric ulcers.
However, some question remains as to whether the technically appreciated end point of complete small bowel visualization is preferable to the more clinically relevant end point of diagnostic yield.
38 By being able to use invasive cancer as the relevant end point, our analysis gives a more evidence based answer to the ongoing discussion on continued screening in women with several negative smear results by age 50.
Key to this procedure is defining a relevant end point.
This included randomized subjects who received at least one dose of study treatment, had a baseline measurement of the relevant end point, and had at least one on-treatment measurement of the relevant end point.
The inclusion of more clinically relevant end-points into pre-clinical trials may aid in more accurate identification of potential drug candidates to translate into the clinic.
Furthermore, a more clinically relevant end-point could have been used.
