However, with the availability of the PDE4 inhibitor Roflumilast we decided to change to this approved COPD treatment, to include a more relevant positive control in the low-dose LPS challenge model that is planned to be used mainly in proof-of-concept studies with novel anti-inflammatory treatments developed in the field of COPD.
are more relevant in controlling deposition of deep-water sands than sporadic long-term events that last for thousands to millions of years (e.g., sea-level lowstands).
guyanensis infectivity in murine infection models, suggesting that IFN γ can be more relevant for controlling L. (V).
Although physicians' assessment of patient compliance appears to be strongly related with glycemic control [ 13], its prognostic value was found to be independent of glycemic control in this study and prognostically more relevant than gylcemic control.
More relevant to malaria control, is the finding of bistable behaviour in regions of mesoendemic transmission, such as Foni Kansala and Sukuta.
In the presence of a more relevant VEGF angiogenic control, SU1498 (∼IC50 tyrosine kinase activity) produced a ∼60% reduction in stimulated EC tubulogenesis indicating a tight association between VEGFR-2 tyrosine kinase activity and our detection of EC tubulogenesis.
Methods such as BayesA/BayesB [ 1] or least absolute shrinkage and selection operator (LASSO) [ 26] are more relevant for traits controlled by few er) genes of large(r) effect and are supposedly better at zeroing out (shrink) loci of negligible effect [ 27].
However, the p-values were reduced for the ALS vs. mimic disease control subgroup comparison (Table 3, first row) relative to the ALS vs. all disease control subgroup comparison (Table 2, "ALS vs. DC") suggesting a stronger trend toward statistical significance when cystatin C is used to differentiate ALS patients from this more clinically-relevant control group.
A main advantage is the internal control value (μc) represented by the baseline, which is more relevant than an external control, because it is available for each individual experiment.
However, C/EBPβ seems more relevant in cancer cell control in a positive way, since it is hormonally controlled and involved in cell proliferation, whereas C/EBPα is predominantly expressed in the terminal differentiation phases of epithelial cells.
