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The structural impact of the two new degrees of freedom in both molecular analogs was dramatic, in such a way that some characteristic features from α-helices displayed by the native peptide became lost in the new analogs, displaying more relaxed conformations.
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This change in conformation was dependent on the duration of the treatment; i.e., longer treatment resulted in a less supercoiled and a more relaxed conformation.
We also detected that histone deacetylase (HDAC) activity was reduced by 52.74% (P=0.017) compared with control samples, indicating that chromatin exists in a more relaxed conformation in treated samples.
The binding pose presented in Fig. 2F positions the carboxyl group into a hydrophobic subpocket in the roof of the substrate binding site, but it offers a significantly more relaxed conformation to the tetrahydroisoquinoline.
The tertiary structures of the Glps, which range in length from 266 332 amino acids with predicted molecular masses from 28.6 35.8 kD, appear less constricted in the central pore due to a generally more relaxed fold conformation and an uncharged Thr on TMD5 of Glp1_v1 and −1_v2 (Fig. 1d, Additional file 1: Figure S1A).
The greater distance between these two clusters in LMNA mutant nuclei is consistent with a more relaxed and open conformation to the chromatin in this genomic region and may also reflect altered interactions with transcription factors and transcriptional machinery.
Perhaps more flexible insertions that include dihalo GC correct pairs and mono and dihalo GT mispairs can occur when the pol β thumb and finger domains are in a more relaxed, partially open conformation.
The first intermediate exhibited D-ring isomerization, whereas the second intermediate exhibited a more twisted chromophore conformation but a more relaxed protein environment.
"He's way more relaxed.
They're the more relaxed team.
Other fans take a more relaxed approach.
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