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1, 2 Previous studies showed slightly more relapses in patients treated with ivermectin.

Importantly, there is evidence that this patient group suffers from more severe complaints and more relapses in substance use than SUD patients without comorbid PTSD [ 4, 5].

This analysis shows that patients with two or more relapses in a given year have higher resource utilization and are more costly in the following year than those with less than two relapses.

However, during follow-up there were more relapses in the placebo group (3 vs. 1 in the experimental group) and besides, there was one late positive sputum conversion to negative among the IFN receiving patients.

A total of 19,219 patients met the study criteria; 94.7% (n=18,202) had less than two relapses and 5.3% (n=1,017) had two or more relapses in 2009 (Table  1).

For patients "off" treatment, the ScHARR model uses a matrix of transition probabilities derived from the actual progressions seen in the Ontario dataset (using a subset of 314 patients who were judged to have fulfilled the Association of British Neurologists' criteria experiencing two or more relapses in the previous two years at baseline).

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Finally, more relapses occurred in older patients (>70 years), namely, 17%% pre-R vs 39%% R era (P = 0.003).

However, there were more relapses and deaths in the group of patients treated with darbepoetin alpha.

Some of the increased costs could be due to reduced medication adherence resulting in more relapses [ 31].

Baseline completes were also more likely to have reported more relapses on their profile in the 2 years prior to the survey, but this may represent different levels of engagement on the website rather than true disease severity; a similar explanation may underlie for the similar pattern for most recent MSRS score from the patients' profiles.

Thus, pediatric clinical protocols focus on reducing or eliminating radiation; however, multiple clinical trials have shown that including TBI is more effective than chemotherapy alone, and even minor reductions of TBI dose have resulted in more relapses (Shi-Xia et al., 2010, Clift et al., 1998).

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