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ADAMTS13 deficiency was associated with more relapses during treatment and with a good renal prognosis.
Patients were divided into two cohorts: patients with HRA (HRA cohort) who had two or more relapses during 2009, and patients without HRA (non-HRA cohort) who had 0 or 1 relapse during 2009.
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As the relapse has been found in a biopsy after 2 years and only 12 patients have passed this checkpoint to date, it could be suspected that even more relapses might be disclosed during longer follow-up.
Most of these patients (69%%) only had one episode during the period of registration, the rest had one or more relapses.
Importantly, this result indicates that psychoeducation is an effective tool not only during a patient's first episode, but also after one or more relapses.
She has had no more relapses, she said.
"It may lead to more urges to smoke or more relapses," Primack said by email.
Patients with two or more relapses were classified as frequent relapses whereas those with no or one relapse were categorized as infrequent relapses.
Individuals with more relapses obtained higher scores.
More relapses in the first 2 years were related (HR = 1.1; P = 0.003) to a higher probability to convert to secondary progressive multiple sclerosis; relapses in Year 2 were marginally (P = 0.02) more predictive than relapses in Year 1. Latency between disease onset and onset of progression was significantly (P = 0.014) longer in groups with 1 versus ≥3 relapses during the first 2 years (Table 3).
Natalizumab patients also had significantly more relapse-free time than platform patients during the 12-month follow-up period.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com