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The single mouse 3'RR differs from the two human ones for the presence of 4 more regulative elements with the double copy of one enhancer at the border of a palindromic region.
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Most likely more sophisticated methods are needed to understand the complex interplay of regulative elements within a cluster as recently shown for regulatory elements of odorant receptors in Drosophila [ 100] and their distribution within clusters.
The Retrieval of non-coding Regulative Elements from annotated genome databases (RRE) software was used to design primer pairs to perform chromatin immunoprecipitation analysis for the Axl gene.
So, on one particular time scale certain regulative elements can be neglect due to their apparent weakness, but they may nevertheless dominate the system on a different scale.
Microarray data experiments such as this may lead to the discovery of regulative elements which serve as powerful tools for expression of commercially valuable recombinant proteins in plants, and which are not circadian-sensitive.
One possible explanation for the maintaining of the clusters is the sharing of regulative elements [ 99], however, our expression data do not support this theory since genes from the same cluster show partially unrelated expression.
Time-line patterns are a regulative element in many kinds of African music, especially dance music along the West African coast, in western central Africa, and in a broad belt along the Zambezi River valley from Zambia into Mozambique.
The length of 5′-UTRs of coding sequences is variable, zero for leaderless transcripts and especially long for genes regulated by cis-regulative elements such as riboswitches.
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