Our results indicate that consolidated memories may be far more refractory to modification or elimination than generally supposed.
Cast SHS powders are obtained by mechanical grinding and dispersion of ingots of refractory compounds and corundum or heterogeneous systems consisting of two or more refractory compounds.
Given the magnificence of his success, there's little wonder that he lacked the shadier, more refractory genius of a Caravaggio, a Rembrandt, or a Velázquez.
Hence, activin A produced following chemotherapy-induced DNA damage may increase the tumorigenicity of resident DCIS lesions or render remaining IDC tumors more refractory to treatment.
When further enhancement is needed for other cell types, or patient's blood MNCs that are more refractory to reprogramming by the current episomal vectors, we can easily add additional reprogramming genes over the 5 6 transgenes we used.
These observations may have important clinical implications with regard to chronic or transformed migraine, which is known to be more refractory to treatment [23].
This might become especially relevant for the generation of iPS from adult human somatic cells for clinical applications, since these cells appear to be more refractory to reprogramming than other cell types, such as adult stem or progenitor cells.
Hence, albeit for hitherto unknown molecular reasons, BDNF expression seems to be much more refractory to CB1 receptor activation in the cortex than in the striatum or hippocampus.
Moreover, the ODC domain is more refractory to change and is dependent on the presence of the so-called linker or hinge region of the bifunctional complex for activity [ 111, 114].
Native platinum was often found with two other metals, iridium and osmium, which were even denser, harder, more refractory.
