As shown in Figure 2C and D, the CD10 subpopulation was also significantly more refractory to fluorouracil in Detroit562.
Therefore, AFL appears to be an arrhythmia with a higher impact on HRQOL than that of AF because it is more symptomatic, more refractory to pharmacological treatment – in terms of control of both heart rate and rhythm – and leads to a greater number of hospitalisations than AF.
Hence, albeit for hitherto unknown molecular reasons, BDNF expression seems to be much more refractory to CB1 receptor activation in the cortex than in the striatum or hippocampus.
All of the genes examined were more refractory to demethylation and activation in the hTERT-1604 human fibroblasts than in the mouse NIH 3T3 fibroblasts, most likely because the latter, older cell line has become more responsive to culture conditions over time.
Children with polyarticular JIA tend to have a more refractory course in comparison to those with fewer affected joints.
Consequently, that could jeopardize the baseline comparability of groups since it could be interpreted as certain channeling effect toward including more refractory patients in the generic cohorts.
Bias by indication includes the notion that clinicians were aware of the methotrexate failure in a patient's history when they decided to re-employ methotrexate, selecting the more refractory patients in whom no other options were deemed valuable.
It is just that for these became more refractory to non-orthologous displacement in later biotic evolution.
As shown in Figure 2A and B, the CD10 subpopulation was significantly more refractory to cisplatin than the CD10 subpopulation in both FaDu and Detroit562.
CAIX transcript levels were more refractory to suppression by 17-AAG in both cell lines at earlier time points, while the remaining HIF transcripts in UMRC2 cells demonstrated a rapid and maximal suppression by 2 h.
Terminal delirium in AIDS, as in other terminal diseases, is more refractory to treatment.
