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The more red cells, the more oxygen-carrying hemoglobin is in the blood.
When oxygen tension falls, more red cells are produced and the red cell count rises.
More red cells meant significant performance gains for cheating cyclists and ultimately brought the sport its most damaging doping scandals, including police raids at the 1998 Tour de France.
The leatherback has more red cells in each unit of blood than other reptiles, up in a range similar to that of mammals, a trait that allows it to carry sizable quantities of oxygen in its circulatory system during prolonged submersion.
In short exposure time (10, 30 and 60 min) at sublethal NFAP2 concentration, same percent of the cells was counterstained with PI in the treated and untreated samples (ca. 1 % of the total cell number), but after 16 h of incubation three times more red cells were counted in the treated sample than in the untreated control reaching a statistically significant difference (p = 0.00004).
On the other hand, as a result of medical progress, more red cells are required [2, 3] due to more complex surgical procedures, increasing number of transplantations, advances in hematology and oncology for which transfusions are necessary [3 5], and aging of the population [6, 7] with increasing rates of medical interventions with old age [8].
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This effect could generate more costs, more manipulation and more red cell losses, which could also impact on patient well-being.
The concurrent dose-dense regimens were associated with more red-cell transfusions, more grade-3 emesis and more post-chemotherapy neurotoxicity than the sequential approach, all of which may be particularly relevant in older patients.
Any decrease in DO2 might have been recognised earlier by ScvO2 than CVP and resulted in more frequent interventions, similar to the results of Rivers et al., who (although in septic patients) also found that the patients assigned to early goal-directed therapy received significantly more fluid, more red-cell transfusions and inotropic support in the initial phase of resuscitation [ 20].
Patients who developed delirium had comparable lowest intraoperative hemoglobin but received more packed red cells and more inotropic drugs.
These erupt from the cell, reinvade the bloodstream, and colonize yet more red blood cells.
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