Sentence examples for more recurrent mutations from inspiring English sources

Since PCR-based cost-efficient testing for BRCA1 and BRCA2 can detect mainly pre-selected mutations, the more recurrent mutations included in the screening, the greater efficiency of the testing.

For example, the procedure with c m = 3 and c r = 2 will prefer one recurrent mutation than a double recombination crossover (gene conversion) at a single inconsistent site, but will prefer a double crossover than two or more recurrent mutations at continuous sites.

We report herein the development and validation of two multiplexed assays designed to detect in DNA from FFPE tissue more than 40 recurrent mutations in nine genes relevant to existing and emerging targeted therapies in lung cancer.

More importantly the conserved recurrent mutations in the 10 genes were highly correlated with pathway deregulation, which further predicted patient clinical outcomes.

The results can be found in the Supplementary file 2. In addition, mutations more recurrent than expected are shown in Supplementary file 5. We have updated our manuscript accordingly.

Do bigger datasets, especially ones containing groups of more closely related chromosomes, lead to better recovery of recurrent mutations and thus more reliable time estimates?

Adult-SHH medulloblastoma tumors show greater numbers of recurrent mutations and more mutations per tumor than do pediatric tumors, and mutations in SMO are common in adult cases.

Thus, given that parental relationships can be established, this method may function as a way to comprehend more complex fitness relationships for recurrent mutations.

Since we are genotyping patient samples, which are more likely to contain relatively recurrent mutations on the target site, the probability of observing heterozygous and homozygous variant sites is higher than that expected from a random site in a normal population.

Our approach also allowed us to identify 1652 total mutations (including recurrent mutations that occurred more than once per mouse), permitting clonal expansion correction and making the assay 50%% more sensitive in detecting increases in mutation frequencies.

15 out of 27 samples (55.6%) had one or more mutations in 10 genes with recurrent mutations.