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Even more recently, transgenic mice lacking PKMζ demonstrate normal LTP, questioning the necessity of PKMζ The long-term stabilization of synaptic changes is also determined by a parallel increase of pre- and postsynaptic structures such as axonal bouton, dendritic spine and postsynaptic density.
More recently, transgenic mice were developed which overexpressed mutant tau by 7 13 fold, resulting in mice that develop a tauopathy associated with neurodegeneration and impaired cognition [25].
More recently, transgenic mice expressing GFP under the control of the POMC promoter have been shown to selectively and transiently label newborn dentate granule cells [26], [51].
More recently, transgenic mice expressing GFP in newborn dentate granule cells under the control of the proopiomelanocortin (POMC) or the doublecortin (DCX) promoter have been characterized [26]-[29 [26]-[29
More recently, transgenic mice were generated with wt human HER2 under the whey acidic protein promoter; however while HER2 was expressed in the mammary glands, no mammary neoplastic transformation was ever detected in any animal [5].
More recently, transgenic models (Table 1) have facilitated research into fibroblastic mechanisms that drive fibrosis.
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More recently, a transgenic mouse model of POAG has emerged.
More recently, focused transgenic manipulation has added novel variants (Table 1).
More recently a transgenic mouse model of MERS-CoV has been published (Agrawal et al., 2015).
More recently the transgenic and knockout technologies have yielded mouse strains with specific genetic alternations or deficiencies that result in breast cancer development.
Within the past few years, several cell culture models as well as single, double and, more recently, triple transgenic mouse models have been developed that reproduce diverse aspects of AD.
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