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This was subsequently reformulated in the 90s as the magnocellular or M-pathway deficit hypothesis [ 7, 8], and more recently refined further as an impairment in the dorsal M-pathway to parietal cortex [ 9, 10].
This concept – cancer immunosurveillance –named and further developed in the late 1950s by Burnet and Thomas [ 2, 3] was more recently refined by Schreiber and colleagues to reflect the additional influence host immunity has in shaping the immunological phenotype of tumor cells, a concept called cancer immunoediting [ 4].
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More recently, with refined techniques and advances in molecular biology, the identification of CTCs via nucleic acid-based methodologies and PCR has developed into a useful tool for the detection of occult metastases (Allan and Keeney, 2010).
The guru Waldfogel has recently refined his calculations... using a new survey to estimate that, per dollar spent, people value their own purchases 18percentt more than they value items they receive as gifts.
We recently refined the Tm-assay by using a molecular beacon as an internal control for temperature variations over the heat-block in the thermocycler and an automated analysis program for more precise and unbiased Tm acquisition.
More recently, Stones has refined and extended structuration theory to accommodate the complexity and inherent contradictions of the social order in today's globalised, multicultural, networked and technology-dominated society [ 33].
More recently, these criteria were refined by the Acute Kidney Injury Network, but basically they rely on increases in serum creatinine or decreases in creatinine clearance [ 6].
More recently, models have been refined to include tissue specific activation resulting in gene amplification, analogous to human HER2+ breast cancer [ 8], as well as temporal control where transgene expression can be activated or inactivated [ 9].
More recently, this has been refined to six subsites (designated as A, B, C, D, D′, and E) by Stowell et al. (2008), who conducted a detailed dose response analysis of the binding of Gal1, galectin-2, and Gal3 to a microarray containing hundreds of structurally diverse glycans.
More recently, this theory has been refined, linking extroversion to the function of dopamine, a chemical that plays an intimate role in the brain circuits which control reward, learning and responses to novelty.
More recently, the grouping has been refined somewhat and the fantails have been classified in a "core corvine" group with the crows and ravens, shrikes, birds of paradise, monarch flycatchers, drongos and mudnest builders.
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