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The role of genetic factors and gene-environment interactions is studied using the candidate gene approach and more recently genome wide association studies, in which our data are often combined with those from other studies in the context of the large collaborative CHARGE consortium [ 47].
This was first shown for a small selection of genes (summarized in [ 50]), and more recently genome wide by combining ChIP-seq, microarrays and RNA-seq in ESCs [ 51], CD4+ T cells [ 52, 53], macrophages [ 32], AtT-20 (pituitary) cells [ 54] and conventional DCs [ 44].
More recently, genome sequence data in several species in the Marasmiaceae, to which L. edodes belongs, have become available in public databases for Omphalotus olearius, Dendrothele bispora, Moniliophthora perniciosa, and Gymnopus luxurians, allowing comparison of laccases among closely related species.
Molecular studies and, more recently, genome and transcriptome sequencing have uncovered the complexity of RNA processing.
More recently, genome scans have been used to search for chromosome regions under selection (e.g., Hohenlohe et al. 2010).
More recently, genome wide association studies (GWAS) have been used to identify variants associated with infection, control of viral replication, and elite controller status [ 1, 7- 9].
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Much has been learned about the genomics of AD from linkage analyses and more recently, genome-wide association studies.
More recently, genome-wide association studies (GWAS) identified associations of common SNPs at 6 different genomic loci (CYP4V2, SERPINC1, GP6, F5, ABO and HIVEP1) [ 7- 9].
More recently, genome-wide chromatin immunoprecipitation studies [14], [21], [22] have been performed in different cellular contexts to identify approximately 1300 direct binding target sites of Myc.
More recently, genome-wide association studies, an approach that compares the frequency of hundreds of thousands of SNPs distributed evenly throughout the genome, have been successful in identifying low penetrance susceptibility variants for breast, colorectal and prostate cancers [20] [25].
More recently, genome-wide analysis using inbred mouse strains has revealed that a considerable number of chromosomal regions that enhance control of infection with different Plasmodium species (reviewed in ([3]).
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