As well as providing rejection prophylaxis, and treatment for steroid-resistant rejection episodes, it is used to help avoid delayed graft function (DGF) in at-risk individuals and, more recently, to facilitate steroid-sparing and calcineurin inhibitor (CNI -sparing regimens in the quest for reduCNI -sparingm moregimensafter organ transplantatinn.
More recently, biotechnological development facilitated the construction of GM plants.
The majority of what we know about AS is based on conventional single-gene approaches though more recently new technologies to facilitate genome-wide studies have been used [2], [34], [35], [47], [50] [54].
More recently, chemical biology approaches have facilitated the development of small molecule- and protein-based methods for direct detection of distinct oxidative cysteine modifications.
Marker-assisted selection [ 11] and more recently genomic selection [ 1] have facilitated greater accuracy of EBV and lower correlations of EBV between relatives [ 12], particularly in younger stock that have not had any performance measurements yet, or if the trait is sex-limited (i.e. milk production), is hard-to-measure (i.e. carcass traits), or has a low heritability (i.e. reproduction).
More recently, transgenic models (Table 1) have facilitated research into fibroblastic mechanisms that drive fibrosis.
More recently, however, PCR-based assays have facilitated the detection of M. genitalium in clinical samples [ 4] and a significant association has been demonstrated between M. genitalium and NGU [ 5, 32].
Another interesting secretatory protein is podocalyxin (PODXL), a sialoprotein, which was first identified in the renal glomerular podocytes [ 55] and more recently as a selectin ligand that facilitates metastasis [ 56].
More recently, online web-based risk calculators have facilitated implementation of more complex risk prediction tools into clinical practice while minimizing the need for additional cumbersome bedside calculations.
More recently, the FBI has been accused of facilitating terrorist plots in mainland America after major investigative exposes by the New York Times and The Intercept.
