More recently, reprogramming adult differentiated cells to a pluripotent state (iPS) became possible, and later, one type of differentiated cell could be directly reprogrammed into another (e.g. fibroblasts into neurons) without reverting to pluripotency.
Thus, the cultivar groups Asiaticus and Albus possibly have diverged more recently, as they were less genetically differentiated, while the cultivar groups Luteus and Aurantiacus, which displayed greater genetic differentiation, might have diverged earlier.
More recently, it was shown that adult humans retain differentiated brown adipose tissue depots, (Cypess et al., 2009; Virtanen et al., 2009) fostering renewed enthusiasm that brown fat activity could be stimulated in adult humans as an anti-obesity therapy.
More recently, efficient tumour cell killing by IgA EGFR by differentiated human macrophages was demonstrated even at low E T ratios (Lohse et al, 2012).
More recently, using ex vivo cell-expanded MSCs, either hepatic differentiated or undifferentiated MSCs were used to treat liver cirrhotic patients (10, 44).
25 More recently, Richand et al concluded that reductions in strain parameters differentiated HCM from physiological LVH in professional soccer players.
More recently, the combination of B-lines and NT pro-BNP differentiated acute decompensated heart failure from both asthma and COPD in a group of 218 emergency department patients [ 44].
More recently, induced pluripotent stem cells (iPSCs) have been generated by direct reprograming of differentiated cells (Takahashi & Yamanaka, 2006; Buganim et al, 2013).
More recently, it was observed that retinoblastomas containing cavitary spaces, indicative of well-differentiated retinoma areas, did not show a substantial decrease in size after chemotherapy (Mashayekhi et al., 2005).
The enzyme dopa decarboxylase (DDC)(catecholamine biosynthesis) has more recently been shown to be expressed in various NETs, such as bronchial carcinoids and poorly differentiated NE carcinomas of the lung (Uccella et al, 2006).
