More recently, administering the ROS scavenger edaravone to patients with AMI immediately prior to reperfusion significantly reduced infarct size and reperfusion arrhythmias [ 25].
More recently, tramadol administered by intravenous route alone or in combination with paracetamol has been demonstrated effective in the acute treatment of migraine [96 98].
More recently, PASS was administered to patients affected by RA.
More recently, TNP-470 administered as a protracted infusion in combination with paclitaxel and carboplatin has yielded interesting efficacy data in patients with NSCLC (Blumenschein et al, 2002).
More recently, the same group administered their modified version of the LDQ to episodic migraine patients, chronic migraine patients overusing acute medications and patients suffering from rheumatic disease [22].
More recently, prophylactic treatment is administered more stringently and is often started before the onset of joint damage and after no more than 1 or 2 joint bleeds.
This applies for classical specific immunotherapy with allergen extracts or, more recently with recombinant allergens, administered via subcutaneous injection or via the sublingual route using tablets or droplets.
More recently, human recombinant Ang-1, administered 8 hours before and in combination with LPS, also protected mice against pulmonary hyperpermeability in vivo through a p190 RhoGAP-dependent mechanism [ 11].
Velikova et al. and Allenby et al. report that more recently, electronic means of administering QOL assessments have been introduced which combat some of the problems associated with the printed forms and optically read systems.
While most studies have utilized single oligos either administered alone, or more recently in combination therapy with other drugs, some investigators have administered more than one oligo in a combined administration or have designed oligos which target multiple proteins (those which share mRNA sequence homology).
