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It is intriguing that 6 pairs of tandem duplicates are represented as 'ancient tandem genes' within more recent whole genome or segmental duplicate clusters.
More recent whole genome gene expression analyses have identified a subset of glioblastomas that overexpress transcripts of ECM components, corresponding to a mesenchymal gene expression profile and being associated with worse prognosis [ 7- 9].
Clusters 5 and 7 have similar gene content (three TRMD segments) and share greater nucleotide sequence identity to cluster 3 and represent more recent whole cluster duplications that would have followed the duplication of an additional D segment in this lineage [ 14].
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A more recent whole-genome duplication is suggested for the Actinopterygian branch [ 61].
Additionally, C. sativa experienced an independent and more recent whole-genome triplication event than the event in Brassica.
More recent whole-body imaging protocols have been established allowing the evaluation of almost all relevant striated muscle groups.
On the other hand, more recent whole-genome duplications challenge read mapping by causing a twofold increase in chromosome number and DNA sequence while preserving gene order, coding and noncoding sequence, and chromosomal elements such as centromeres and telomeres.
The studies that reported these first frequencies, however, used CGH arrays and small sample sizes (n = 40, [ 4] n = 55 [ 4] and n = 270 [ 6]) compared to more recent whole-genome studies.
In a more recent study, whole-genome sequencing of the relapse of a lobular breast cancer 9 years after diagnosis revealed that some of the mutations present in 1 to 13% of the cells in the original tumor were enriched in the relapse tumor [ 10].
In contrast to recent studies employing primarily nuclear DNA sequences, a more recent study of whole mitochondrial genomes [ 26] failed to retrieve many of the well-supported clades identified by nuclear gene studies.
More recent studies employing whole genome data reported high genetic similarity of European Jews to Druze, Italian, and Middle Eastern populations (Atzmon et al. 2010; Behar et al. 2010).
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