More recent and useful CreER variants include MerCreMer, a double fusion of Cre with two ERTM domains [7], and CreERT2 (G400V/M543A/L544A triple mutation of human ER-LBD) [8].
For example, for useful more recent discussion of the more general issue of whether there can be necessary connections between distinct existences, see Wilson 2010.
Thus, studying a fluid situation at one period in time (1999) is not optimal, and more recent longitudinal data would be useful and should be pursued as future work.
While the GBMD is useful to identify long-term migration trends ad patterns, there are less useful for analysing more recent trends in African migration.
Serologic assays detect chronic or persistent infections but are less useful for diagnosing more recent infections.
Longer ROH tracts (for example, >500 kb) provide a useful measure of more recent consanguinity.
However, their faster rate of evolution in comparison to nuclear genes can be useful for resolving more recent relationships [ 65].
For example, tests based on the SFS are primarily powered to identify older selective events and recently completed sweeps, whereas long-range haplotype tests are more useful to identify more recent events (<30,000 years ago) and incomplete or partial sweeps [ 41].
Nevertheless, in the absence of more recent data it still provides some useful information on pharmacists' work patterns, and whether they differ depending on route of entry for those with a registered address in Great Britain.
Even though mitochondrial markers coalesce faster than nuclear markers due to the smaller effective size and the lack of recombination, microsatellites have a much faster mutation rate which makes them useful to detect more recent processes [ 50, 51].
