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Cyclophosphamide remains the most effective immune suppressive, and more recent protocols have minimised its toxicity.
Even more, recent protocols on the topic also warn against the impact of the protein solution composition (buffer, ionic force, etc).
The more recent protocols select subsets of relays, compute the expected number of retransmissions for each subset, and choose the one that minimizes transmissions.
More recent protocols involve the use of paired-end sequencing.
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In the second and more recent protocol, the treatment was completed by local RT with 21 Gy on tumor bed before surgery [ 17].
A more recent protocol, although providing the ability to perform precapture multiplexing on both solid-phase and solution-based TGE is optimized for SOLiD sequencing [ 11].
More recent treatment protocols have replaced cranial irradiation with intrathecal chemotherapy as standard central nervous system disease prophylaxis and treatment.
In several more recent clinical protocols for neuroblastoma, this apparently optimal order of drug administration has not been retained.
All of these studies suffer from diverse limitations in design or reporting when compared to more recent experimental protocols and reports.
Differences could be due to the inclusion in our study of a larger number of survivors treated on more recent chemotherapy protocols.
However, more recent treatment protocols, including high dose cytarabine, rituximab and autologous stem cell transplantation (ASCT), have achieved long-term remission in subgroups of patients (Geisler et al, 2008; Romaguera et al, 2010).
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