On a time scale of several years, all previously circulating lineages are globally replaced by new ones, sharing a single and more recent common progenitor (2 8 years) in the past [ 5- 7].
More recent experiments demonstrate that progenitor cells do indeed possess indefinite self-renewal capacity, with the population turn-over driven by forced displacement by new pro-T cells 7.
Although originally CEPs were discriminated from mature CECs mainly by the presence or absence of CD133 progenitor markers, more recent data have cast serious doubts on this premise (Timmermans et al, 2008; Yoder and Ingram, 2009).
Similarly, a more recent report showed mouse SOX9+ progenitors in embryonic lung can be grown in vitro as organoid and transplanted to generate mouse alveoli (Nichane et al., 2017).
However, a more recent study argues that Cux2+ progenitors can become both upper and deeper layer neurons in the developing cortex (Guo et al., 2013).
More recent studies have demonstrated that also progenitor populations, as CD34+ cells, can sustain persistent KSHV infection when infected in vitro, and may therefore act as possible infection reservoir [3].
A more recent study described the differentiation of progenitor cells into ECs in a collagen matrix.
The age of the crassus group is estimated at ~4 Myr while colonization of the LCR by the brichardi-brachyrhinus progenitor was considerably more recent, dated at ~0.5 Myr.
Since few lineages seem to have founded this weedy group, the divergence times obtained may represent the coalescence of these founders with the entire indica gene pool, and not the more recent split between weedy rice and progenitor.
Similar results can be drawn by a more recent study addressing the role of Rac1 on interneuron progenitors originating in the MGE (Vidaki et al. 2012).
