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Talenfeld and his colleagues now hope to do more comparative studies of these procedures, using more recent patient data and including cost comparisons.
Dr. Talenfeld and his colleagues now hope to do additional comparative studies of these procedures, using more recent patient data and including cost comparisons.
The Care Quality Commission, the NHS care regulator, pointed out that more recent patient experience surveys had found that far smaller proportions of patients than those highlighted by the LSE report were unhappy with their care.
The favourable survival may be due to a more recent patient cohort in the present study and, possibly, patient selection.
It would be most interesting to determine in more recent patient series whether hormone receptor status is associated with distinct patterns of recurrences to individual metastatic sites.
Our study supplements the work of Labelle and colleagues by evaluating additional treatment variables in a more recent patient cohort enrolled between 2008 and 2010.
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The results from the more recent patients are summarized in Table 1.
It might be that more recent patients who have transfusion are more anaemic than patients earlier in the series.
Furthermore, such models can be systematically recalibrated over time, by relearning the models on an updated development cohort with more recent patients.
While the authors correctly point out that when considering treatment options at initial diagnosis it should be the patient's absolute risk of a further ipsilateral tumour that determines decision-making, the authors' own findings of increased survival in the more recent patients managed aggressively with chemotherapy mean that more women will be surviving to develop ipsilateral disease.
The consistent prognostic relevance of MMP-2 is underlined by Figure 2B, in which the old group of patients (n=50) and the more recent patients group (n=31) are independently subdivided based on a low or high MMP-2 antigen content of the carcinoma, using the same cutoff value.
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