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These data are an updated version of the data of Patterson et al. (2006), updated and recurated by Burgess and Yang (2008) to incorporate more recent genome assembly sequences and to generate high-quality alignments of genomic regions instead of single variable sites.
A more recent genome comparison between pathogenic and non-pathogenic isolates of Neisseria meningitidis, a normally harmless nasal-dwelling bacterium that is also known to cause meningitis, found only one noticeable difference between the two groups: a cluster of prophage genes that turned up in 29 of the disease-causing isolates but only 2 of the 20 benign bacteria7.
After investigating characteristics of the more recent genome annotation, we analyzed earlier developments directly following the release of the first genome sequence drafts.
For the rhesus macaque, we used a more recent genome sequence (Yan et al. 2011).
Consistent with those previous analyses, there was no evidence of more recent genome duplication events in our YST individuals.
More recent genome wide studies using transcriptomics have revealed that lineage specific genes may also be important and require study [ 24, 25].
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Here, I attempt a synthesis of the earlier single-promoter type of analysis with the more recent genome-wide studies.
Early attempts to screen up to 400 candidate genes for association with late-onset sporadic AD (LOAD) resulted in a low yield, More recent genome-wide association studies (GWAS) have found 19 areas in genes that appear to affect the risk.
More recent genome-wide studies show that only ~10% of human genes contain TATA-dependent promoters [ 20, 35].
The relation of MI to rs3764261 described in the more recent genome-wide study was adjusted for age and sex, but not for other potential confounders.
More recent genome-wide association studies (GWAS) that include different phenotypes, novel designs, and that have examined different population characteristics suggest novel targets and affirm the utility of additional searches.
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