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The efficiency of glycoside prodrug conversion might be improved by design of a prodrug that is more readily activated by human β-glycosidase or by evolution of the enzyme into a mutant form that displays high activity towards these prodrugs.
It is clear that in order to account for both, isomerisation has to be favored, irrespective of chain length for all n-alkanes but with the shorter alkanes being more readily activated (Table 3), whereas the isomers formed are more stable for those derived from short chain alkanes and consequently undergo secondary reactions at a lesser rate.
Whereas, gain of function mutations in Tm increase Tm flexibility lowering the energy required for Tm movement and making the thin filament more readily activated [31], [61].
This contrasts with reports that BakY108A was more readily activated than wtBak.
Several reports have shown that cell surface receptor-bound plasminogen, or plasminogen coupled to its soluble receptor, are more readily activated to plasmin than free plasminogen [ 21- 23].
Again, like the OPs, carbamates are usually applied as chemically modified protoxins that are more readily activated in insects than mammals, such as the N-sulfonyl carbamates (Kinoshita and Fukuto 1980; Fahmy and Fukuto 1981).
Similar(51)
The team found that embryonic cells that form the face are more sensitive to the mutation because they more readily activate a pathway that induces cell death in response to stress.
Still, it is conceivable that human muscles other than the principal biopsy-sampling muscle, quadriceps, more readily activate α1 AMPK during contraction.
SP administration would more readily activate NMDA and AMPA receptors leading to increased action potential firing in comparison to before SP administration and thus produce more rapid foot withdrawal.
Therefore block designs might more readily activate cognitive processes such as sustained attention as well as top-down regulation mechanisms including inhibition of sexual arousal.
Antimicrobial immunity involves adaptive immunity, however, which also is readily activated by TLRs [ 45, 46].
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