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The suggestion of more rapidly progressing liver damage in the genotype 2a group found here is also consistent with its higher replication level although the difference in GPT levels may not be clinically significant.
These unique observations found in ALS mice were extended into the ALS patient population where patients with more rapidly progressing disease had decreased numbers of Tregs; the numbers of Tregs were inversely correlated with disease progression rates.
These observations were extended into the amyotrophic lateral sclerosis patient population where patients with more rapidly progressing disease had decreased numbers of regulatory T lymphocytes; the numbers of regulatory T lymphocytes were inversely correlated with disease progression rates.
There is some evidence that DLB patients have more rapidly progressing dementia compared to AD [ 3], and more recent studies also reported a more severe course with shorter survival [ 4], higher rate of nursing home admissions [ 5] and higher costs in DLB as compared to AD [ 6].
Here we have reported that teeth that progress to early stage periodontitis have a more rapidly progressing gingivitis score compared to teeth that do not progress to periodontitis.
Overall, we regard the high propensity of a particular mutant to aggregate as a risk factor for a more rapidly progressing disease.
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Patients co-infected with HCV and HIV more rapidly progress to cirrhosis than those with HCV alone [1], and are at increased risk of death from the end-stage liver disease [2].
It has also been suggested that impairments in glucose tolerance in obese children may more rapidly progress to T2D in this age group compared to adults due to the tendency for obese children to gain excessive amounts of weight [ 22, 23].
The more rapidly progress is made, the less can change externally while the strategy is being executed and the greater the chance of success.
Early onset is associated with a more aggressive, rapidly progressing disease, especially if symptoms appear before 40 years of age [ 16].
As compared to control mice, anti-GITR-treated NOD females exhibited more severe and rapidly progressing sialitis.
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