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Furthermore, small molecules display more rapid tissue distribution and faster blood clearance compared with intact immunoglobulins.
When implanted subcutaneously, faster hydrogel degradation and more microspheres (e.g. 75 mg ml−1) generally induced more rapid tissue and cellular interactions and a greater macrophage response.
It is likely however, that coatings of lower crystallinity can facilitate more rapid tissue attachment since the surface will exhibit a higher specific surface area and will be considerably more reactive than a comparable highly crystalline surface.
Furthermore, small molecules display more rapid tissue distribution and faster blood clearance, compared with intact immunoglobulins.
Protocols compatible with investigators who require more rapid tissue retrieval can be identified and prioritized to ensure data preservation.
Recent publications suggest that smaller high-affinity ligands (MW < 2000 Da) may enjoy a much more rapid tissue distribution compared with antibodies and antibody fragments (Low et al, 2008).
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Tumors exhibit more rapid and pronounced tissue enhancement, often with washout kinetics at delayed imaging [13].
RNA degradation was much more rapid in frozen tissue.
Thus, in a patient with severe sepsis or septic shock, better lactate clearance can be associated with decreased mortality and might arise from more rapid improvement in tissue perfusion.
Utilizing such networks holds the promise of greater research efficiency through a more rapid recognition of physiological tissue responses.
Smad3 null mice exhibit improved and more rapid healing of deep tissue wounds, possibly as a result of reduced inflammatory cell infiltration [ 41], but conversely, Smad3 deletion impairs cardiac infarct scar formation, owing to impaired fibroblast function [ 36].
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