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Excess PR-A levels correlate with poorer disease-free survival and more rapid relapse following tamoxifen treatment [ 26].
Also in the third one, the smaller Stockholm dataset, there was evidence for survival difference, but it did not reach statistical significance.. Altogether, the CHEK2 1100delC gene-expression signature was associated with more rapid relapse of the disease in all three sample sets.
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Medication-resistant patients, female patients, and those with more severe depressive symptoms following ECT had more rapid relapses.
High Gleason scores were associated with more rapid biochemical relapse (P=0.002), time to death after biochemical relapse (P=0.02) and disease-specific survival (P=0.001), confirming the association of these clinical parameters with the progression of prostate cancer.
From the results presented here, it is evident that increasing levels of Raf-1 and/or MAPK are indicative of more rapid biochemical relapse and a more rapid decline into CRPC, which ultimately results in reduced survival times, with tumours showing more severe and aggressive action.
Patients with PR3-ANCA have higher mortality, a higher relapse rate, and more rapid renal deterioration compared with patients with MPO-ANCA [ 18].
This would indicate that multiple sclerosis with progressive onset had a more rapid disability progression than multiple sclerosis with relapsing onset during a given follow-up period, as will be demonstrated below.
Additionally, slope of relapse percentages over time appears to be more rapid with stimulants or GXR than with ATX.
Given this gap between recommended and actual practice, it seems important to investigate whether a higher intensity of treatment will lead to better and more rapid treatment outcomes and is related to lower rates of relapse.
A higher early relapse frequency could be concomitant to a predestined, more rapid clinical course.
Such tumours have a more rapid cell proliferation and are associated with a higher risk of relapse despite adjuvant chemotherapy.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com