Sentence examples for more rapid methylation from inspiring English sources

People with more rapid methylation to DMAs may have more rapid clearance and be less susceptible to diseases.

Finally, once the importance of specific methylation changes is established, the more rapid and technically less demanding methylation specific PCR assays may be used to quickly assess methylation status of the region for high throughput studies (5).

We asked whether the absence of CTCF binding to the Rb promoter is able to contribute, firstly, to more rapid and extensive DNA methylation, and secondly, to faster and robust epigenetic silencing.

Loss of DNA methylation is much more rapid in female than in male mutant ES cells, even though levels of DNA methyltransferases and DNMT3L are the same in male and female ES cells.

Previously, Jones and Chen suggested that because of its rapid methylation upon stimulation, the more proximal CpG -53 site, compared with the five other murine IFNγ promoter CpG sites they examined, is the key CpG involved in the suppression of IFNγ transcription [ 12].

By analysing the extent of phosphorylation of Ddc2, the most proximal target of Mec1, after induction of DSBs, we observed that loss of methylation of H3-K79 leads to more rapid activation of Mec1 and to an increase in the level of phosphorylated species.

In multivariable models adjusted for age, height, BMI, pack-years of smoking, current smoking, per cent lymphocytes, race and baseline lung function, LINE-1 hypomethylation was associated with more rapid decline of FEV1 (β=6.9 ml/year per 1% change in LINE-1 methylation, p=0.005) and of FVC (β=9.6 ml/year, p=0.002).

To test if methylation of H3 K36 by Set2 was necessary for a more rapid S-phase in the absence of Rpd3, SET2 was deleted in a WT and its isogenic Δrpd3 strain.

As a more rapid approach to assess the XCI status of multiple transgenes, we used DNA methylation as a surrogate measure of inactivation, since promoter DNA hypermethylation in females relative to males can be attributed to DNA methylation of the Xi and thus reflects inactivation of the gene (Yasukochi et al. 2010; Cotton et al. 2011).

Supplemental to the simpler and more rapid library generation, we established the utility of the Illumina MiSeq in targeted DNA methylation analysis.

It appears likely that the turnover of DNA methylation in the brain and in neurons, in particular, is even more rapid than in other cell types and organs, perhaps accommodating neuronal plasticity, learning, and memory.