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However, the shapes of the BTCs varied greatly; small pulse inputs resulted in more rapid attainment of peak values that appeared earlier with increases in pore water velocity, whereas large pulse inputs resulted in an opposite trend.
In addition, ICU environmental profiles could be correlated with trajectories of circadian biomarkers, and different environmental approaches to patient care, such as 'virtual darkness' by shortening the day length, could be designed and tested to promote more rapid attainment of circadian rhythms [95].
Thus, differences in fall outcomes between the groups could represent differences in effectiveness for preventing falls or more rapid attainment of similar effectiveness.
Although not superior to intermittent infusion for clinical effectiveness, continuous infusion may result in a reduced risk of renal toxicity and in a more rapid attainment of therapeutic concentrations [ 35].
From a practical standpoint, the use of an antibiotic loading dose along with the prolonged antibiotic infusion should be considered in patients with elevated CrCl to allow for more rapid attainment of the desired antibiotic concentration at the infection site.
This novel delivery system for exenatide has several potential advantages for the treatment of type 2 diabetes such as more rapid attainment and maintenance of consistent therapeutic drug concentrations, 100% adherence with therapy, and improved glycemic control with improved tolerability, perhaps related to more constant and predictable exenatide levels (11).
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In the critical care setting, continuous infusion (CI) of vancomycin may enable a more rapid and consistent attainment of target drug concentrations than standard intermittent administration [ 11].
The shorter (1.5 hours) half-life of CyC compared to creatinine accounts for the more rapid rise and the earlier attainment of a new steady state [ 20].
Better cognitive function and educational attainment confer protection against unemployment and facilitate a more rapid transition back to employment from unemployment, thus reducing the duration of exposure to unemployment-associated adversity.
"They are more rapid.
And those more rapid cognitive losses continued.
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Justyna Jupowicz-Kozak
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