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Whereas the long-term effects of smoking on outcomes such as heart disease, cancer and respiratory conditions are well established, there are many more proximate effects of smoking that go unrecognized and that may differentially affect women and men.
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Adverse childhood experiences (ACEs) have been consistently linked in a strong and graded fashion to a host of health problems in later adulthood but few studies have examined the more proximate effect of ACEs on health and emotional well-being in adolescence.
Long-term and long-distance migration (probably linked to movement to oil-rich middle-east countries) exhibited a stronger effect on education than more proximate migration.
But the more proximate tool, with the greatest known effectiveness, was fiscal policy, especially increased government purchases of goods and services.
Adjusting for negative life events, or increasing stress scores, greatly attenuated the association of female gender with MDD, indicating that the effect of gender was mediated through more proximate social factors.
In our model, distal factors linked to socioeconomic status (SES) have a potential effect on miscarriage via their influence on more proximate determinants.
That Whyatt et al. (2004) showed the relation for cord blood chlorpyrifos levels with newborn growth decrements, but were unable to associate them with self-reported use or air monitoring measurements, suggests that measures more proximate to the site of action may be more predictive of an effect, a main tenet of biomonitoring.
Although predisposing characteristics have only been found to have a moderate effect on of ERVH, in this palliative population they are a more proximate predictor.
If we use a time frame more proximate to the ICU admission and application of ICU therapy, we may have greater sensitivity and power to detect treatment effects compared to later outcome assessments.
(I could have also chosen more proximate destinations, like Barcelona versus Madrid or Frankfurt versus Berlin).
Chabon is a careful guide to his favored artistic outposts, maintaining reassuring ties to more proximate lands.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com