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The participating cells contain information needed to develop everything "downstream," but can never become more proximal structures.
As the grafts made at stage 21 give rise not only to digits but also to more proximal structures (Figure 5C), we also "cropped" GFP-expressing sets of spatial domains at stages 24 and 27 (see methods) so that only the distal part of the domains was considered.
As many of the distal acinar structures have been obliterated or developmentally interrupted in CLD, it is the more proximal structures that are left behind to adapt.
Krn was required in a broader domain including more proximal structures in the legs of T. castaneum compared to the relatively distal requirement for EGF signaling in D. melanogaster legs (Campbell 2002).
These results provide an explanation for the identical phenotype resulting from ectopic expression of either Meis or Prod 1 in distal blastemal cells, that is the proximal displacement and contribution to more proximal structures in the regenerate.
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The maxillary region displayed enlargement of some elements, transformation of proximal structures to more distal identity, and inter-element fusions, though not formation of the anatomical precursor to siphonate mouthparts.
As the current was increased at this receptive field electrode, the latency of the recorded action potential decreased in discrete steps corresponding to excitation of the branching terminal structure at more proximal locations [19].
If distal blastemal cells are electroporated with a plasmid expressing newt or axolotl Prod 1, or axolotl Meis 1 and 2, they relocate to a more proximal location in the regenerate and contribute to proximal structures (Echeverri and Tanaka, 2005; Mercader et al., 2005).
This suggests that previously reported associations may have been mediated, in part at least, by more proximal adolescent psychosocial factors such as family structure and parental relationships.
At the 7q TERRA promoter, chromatin structure was co-regulated with the more proximal subtelomere.
The distal promoter, promoter 1, is active during the aggregation process while the more proximal promoters are active in tip-organiser and posterior regions of the structures.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com