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This more protracted time course of white matter damage, compared to grey matter, suggests that white matter should be a key target for initial therapeutic treatments and that there is a window of opportunity of several days during which agents could be administered to help support white matter survival.
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An expanded study with substantially more temporal samples coupled with extensive medical histories for these patients is necessary to confirm that this observation holds true in larger populations over more protracted time-frames and if so, to determine the factors that drive this phenomenon e.g. frequency of antimicrobial administration.
Studies of spinal cord injury using static compression have highlighted that neuronal loss is much more protracted in time in this type of trauma, than the loss observed after contusion injury.
Consequently, factors such as better performance status are likely to indicate those patients who are likely to have more prolonged progression-free survival and who may therefore receive chemotherapy for more protracted periods of time (Borner et al, 1998).
Typically, divergence time estimates made using molecular phylogenetic approaches have supported a much more protracted timeframe for primate evolution than that suggested by the fossil record [ 27, 33].
Conflicts are becoming more protracted.
Two major developments point to more protracted difficulties.
This means that custody battles are more protracted.
Preliminary data may suggest a more protracted recovery from concussion in high school athletes.
He is currently undergoing a more protracted, though more agreeable test of his staying power.
The end result is still funds raised, but it a much more protracted method.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com