In modelling, we need to build a DE describing molecular binding reactions, such as protein protein binding or one or more proteins interacting with small molecules.
A protein interaction is said to be mutually exclusive, if two or more proteins interact with the same interface on the surface of their common partner.
One possibility could be that the myristoyl moiety of this protein interacts more weakly with cholesterol-depleted membranes.
Firstly, we collected the proteins that are annotated as splicing factors, we next acquired their interaction partners and selected those proteins interacting with more than one protein annotated as splicing factor.
Even though, the components of the ribosome have not been identified as targets of Pho4 in yeast [ 24], more than 30% of the 155 proteins interacting with Pho4 TF [ 26] are classified as ribosome function related according to SlimGO annotation.
The probability distribution of the viral targeting intensity, kv TP) - i.e. the number of viral proteins interacting with a host protein - showed that 32% (366/1,148) of targeted cellular proteins interact with more than one viral protein.
Moreover, each functionally defined ORN expresses only one (or in some cases more) specific odorant receptor protein interacting with one or a limited set of compounds (Hallem et al., 2004; Fishilevich & Vosshall, 2005; Goldman et al., 2005).
Although our data do not support a role for calmodulin or protein phosphatase 2A, the catalytically inactive CaMKIV proteins interact more avidly with CaM-dependent protein kinase kinase (CaMKK), which is restricted to the cytoplasm.
It also showed (Table 2) that weak operon proteins interact more frequently with ribosomal proteins than with strong operon proteins and other weak operon proteins.
Second, some other nonamyloid structure, possibly an interdigitated β-sheet interaction between NICD and one or more other interacting proteins, exists.
