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Following the same successful paradigm as in drug applications, HTA agencies tend to call for more prospective randomised studies, in which PET imaging is considered as an alternative or supplement to conventional diagnostic procedures.
More prospective, randomised studies are needed to confirm these findings.
More prospective, randomised studies are required to compare these different tracheostomy techniques adequately.
In the current study although we didn't aim to analyse the histopathological and molecular biomarkers, more recently, it has been suggested that SBA has striking molecular similarities with CRC [ 9]; this perhaps suggests that much better outcomes should be achieved in SBA if more prospective randomised studies were designed to inform treatment strategies.
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Our concerns focused on the conclusions reached by the NICE panel in the face of two prospective, randomised trials involving more than 1000 patients showing a survival advantage in favour of first-line irinotecan-based therapy (Douillard et al, 2000; Saltz et al, 2000).
For future studies, a prospective, randomised study design would be a more robust approach to this research question.
Kránitz et al 13 demonstrated in a prospective, randomised, controlled trial that a laser capsulotomy resulted in a more stable refractive result when compared with a more variable manual capsulorhexis.
Design: prospective, randomised study.
Prospective randomised comparative study.
Design prospective randomised multicentre study.
Design: prospective randomised double-blind controlled trial.
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