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They also encode a putative holin (Gp21) with more pronounced sequence divergence.
Hence, APs have undergone a much more pronounced sequence diversification in fungi than in other eukaryotes.
Previous binding studies using fluorescence polarization (FP) assays suggested more pronounced sequence selectivity for dSfmbt binding to H4K20me1/2 and H3K9me1/2 as opposed to binding to H3K4me1/2 or H3K27me1/2 (Klymenko et al, 2006).
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At indicated positions, the probability of base pairing is on average more pronounced in the upregulated sequences compared to the downregulated sequences (p = 2.0·10−6, p = 2.7·10−7 and p = 2·10−4 for positions 1, 2 and 3 of the 3'UTR respectively; Wilcoxon-Mann-Whitney two-sample rank sum test).
In D. melanogaster this proportion was higher for coding sequences than for genomic sequences, indicating a more pronounced clustering in the cds than in non-coding sequences (Table 1).
The chronic hemolytic anemia variants in contrast, exhibited more pronounced changes in the dynamic sequence of interactions.
Although a wide range of short read aligners has been developed over the past years (Li and Homer, 2010), none of them has been specifically designed or optimized for aligning short reads against reference genomes with sequence differences more pronounced than those observed among genomes within the same species.
A comparative demographic analysis of all Guinea-Bissau-specific CRF02_AG sequences together with the reference sequences (in total 77 sequences), showed a more pronounced demographic history (Figure 2b).
Higher classification accuracy would indicate more pronounced force differences between the sequences.
In the case of the new ultrasmall archaeal lineages Aenigmarchaeota and Diapherotrites, this problem was even more pronounced due to the incomplete genome sequence coverage for these species.
It was hypothesized that exposure to repetitive loading would lead to decreased tensile strength and increased strain, and that these differences would become more pronounced with greater loading and unloading sequences.
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