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Both KC and MCP-1 had a more prolonged secretion into the BALF, being elevated until at least day 4 post-treatment (Figure 2B and C).
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Consistent with their hypothesis, the authors found that although both groups of adolescents exhibited significantly elevated cortisol response to the TSST relative to their respective baseline levels, depressed participants showed significantly higher and more prolonged cortisol secretion following psychosocial stress induction when compared with control subjects.
However MRI demonstrated that the distribution of gastric secretions in the stomach was abnormal in the patient group such that the exposure of the EGJ to undiluted gastric secretion was significantly more prolonged than in healthy controls.
20 Two dipeptidyl peptidase-4 (DPP-4) inhibitors (sitagliptin and saxagliptin) are approved in the US and inhibit the enzyme that metabolizes endogenous glucagon-like peptide-1; thus, this hormone has a more prolonged effect on postprandial glucose through its effects on insulin secretion and suppression of glucagon secretion.
Hatem et al. [ 3] suggest that the JH-controlled mechanism favors large body size, but at the cost of more prolonged development, whereas eliminating the repression of ecdysone secretion by JH favors rapid development time.
The effect of G-Gly in increasing acid secretion from cultured parietal cells is only seen with more prolonged exposure, similar to the results reported here, suggesting this peptide may have longer term regulatory actions on transcription or processing instead of just stimulating hormone release.
Droughts are becoming more prolonged and more widespread.
At near-lethal temperatures, more prolonged heating caused more mortality.
It's more prolonged use that can get risky.
We're seeing longer and more prolonged droughts.
That could result in a much deeper, more prolonged downturn.
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