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The PT corrected to normal or near normal levels for all doses; more prolonged responses occurred after the higher doses, and there were no episodes of disseminated intravascular coagulation (DIC).
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In contrast, the wild-caught starlings showed a delayed, but much greater and more prolonged response to the human stressor that had failed to return to baseline levels by the end of the observation period.
Whether repeat dosing with anti-CD20 or other agents could achieve a more prolonged response without increasing adverse events is not known.
Removal of this larger rapid component of the response by Zn2+ inhibition revealed the presence of a smaller, later and more prolonged response that reached a peak 15 s after agonist application (Fig. 7D).
Larger objects, such as clumps of bacteria or tissue cells, are phagocytosed over the course of a more-prolonged response.
We further tested this hypothesis by conducting separate analyses of the subjects' maximal (henceforth 'peak') fMRI responses and the more prolonged fMRI responses acquired during the same trials.
Cessation of echolocation clicks was thus a common response to acoustic disturbance in beaked whales studied to date, but sonar avoidance responses were stronger and more prolonged than responses to vessel noise.
And whilst stress responses are adaptive in young people, they might be altered with ageing, leading to exaggerated and more prolonged stress responses.
This situation is very likely to be cell-type-specific, where both complexes may be involved in different stages of the antiviral response; ISGF3 stimulating a rapid and transient antiviral response and STAT2/IRF9 being responsible for a more prolonged antiviral response.
This group had a much higher and more prolonged immune response than those given the traditional booster shot by injection after 40 days had.
Chronic treatment could induce a more prolonged cytokine response that may become more pro-inflammatory and pro-fibrotic, decreasing the beneficial effects seen with acute Tβ4 administration.
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