Sentence examples for more prolonged durations from inspiring English sources

The likelihood of sustained benefits of weight reduction on β-cell function and glycemia in patients with early-onset versus more prolonged durations of type 2 diabetes needs to be determined.

As exenatide requires twice daily administration and does not provide 24-h GLP-1R activation, there has been considerable interest in development of GLP-1R analogues with more prolonged durations of action (Fig. 2) suitable for once-daily or once-weekly administration (17).

In addition, the left inferior frontal gyrus showed a more prolonged duration of activation in the semantic retrieval condition.

The results suggest that frovatriptan has a similar efficacy to rizatriptan, but a more prolonged duration of action.

Unlike P-selectin, previous studies reported that VCAM-1 had different kinetics of expression on human endothelial cells, with a later onset and a more prolonged duration of at least 72 h compared to that of P-selectin [32].

Some of them are labeled as fast triptans and share similar characteristics with sumatriptan, the prototype triptan, displaying a rapid dose-dependent efficacy, with a higher risk of adverse effects, while others seem to have a more delayed onset of the relieving effect on migraine symptoms, but a more prolonged duration of action and a reduced rate of recurrent migraine attacks [5].

In Flag-Ser394Ala expressing cells, Ser487 phosphorylation levels were elevated for a more prolonged duration following both γ-IR and UV treatment as compared to wild type (Figure S4B).

Liraglutide is an investigational human acylated GLP-1R agonist approved in Europe that binds noncovalently to albumin and exhibits a more prolonged duration of action suitable for once daily administration.

The greater sensitivity of C4 cells to TMQ-associated lethality may be attributed to the greater extent of TMQ-mediated DNA damage and more prolonged duration of DHFR inhibition after drug exposure.

Clinical studies have demonstrated that, compared with NPH, glargine has a more prolonged duration of action of up to 24 h due to a slower and more delayed absorption from the subcutaneous tissue, reduced variability, and a relatively consistent, peakless concentration time profile, thus reducing the risk of hypoglycemia [ 58, 103– 105].

In the developed world, the epidemiology may be different because most cases are usually primary infections with more severe clinical manifestations, greater numbers of people with bloody diarrhea (50%, as opposed to 15% in developing countries), and a more prolonged duration of excretion (approximately 15 days, compared with 7 days in developing countries) (28 ).