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In addition, the left inferior frontal gyrus showed a more prolonged duration of activation in the semantic retrieval condition.
The results suggest that frovatriptan has a similar efficacy to rizatriptan, but a more prolonged duration of action.
Unlike P-selectin, previous studies reported that VCAM-1 had different kinetics of expression on human endothelial cells, with a later onset and a more prolonged duration of at least 72 h compared to that of P-selectin [32].
Some of them are labeled as fast triptans and share similar characteristics with sumatriptan, the prototype triptan, displaying a rapid dose-dependent efficacy, with a higher risk of adverse effects, while others seem to have a more delayed onset of the relieving effect on migraine symptoms, but a more prolonged duration of action and a reduced rate of recurrent migraine attacks [5].
In Flag-Ser394Ala expressing cells, Ser487 phosphorylation levels were elevated for a more prolonged duration following both γ-IR and UV treatment as compared to wild type (Figure S4B).
Liraglutide is an investigational human acylated GLP-1R agonist approved in Europe that binds noncovalently to albumin and exhibits a more prolonged duration of action suitable for once daily administration.
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The likelihood of sustained benefits of weight reduction on β-cell function and glycemia in patients with early-onset versus more prolonged durations of type 2 diabetes needs to be determined.
As exenatide requires twice daily administration and does not provide 24-h GLP-1R activation, there has been considerable interest in development of GLP-1R analogues with more prolonged durations of action (Fig. 2) suitable for once-daily or once-weekly administration (17).
In this case, glucose increase was larger in magnitude (∼30 μM) and more prolonged in duration.
One other change from Experiment 1 was the presentation of auditory feedback after each saccade sequence as a motivational aid, in light of the more prolonged testing duration.
These patients had a more prolonged no-flow duration (medians, 3 minutes (IQR, 0.5 to 6.5) vs. 2.5 minutes (IQR, 1 to 6); P = 0.04) and lower mean ETCO2 levels (9 ± 3 minutes vs. 12 ± 2 minutes; P = 0.046) than the remaining patients.
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more long term duration
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