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In the south, resistance to British rule was more prolonged; administration there was confined to keeping the peace rather than making any serious attempts at modernization.
It is likely that more prolonged administration of octreotide would have prevented relapsing hypoglycaemia.
In addition, we cannot rule out the possibility of divergent microcirculatory effects in response to more prolonged administration of the study drugs.
To test the local tolerance of a more prolonged administration three patients received 930-1,000 mg m-2 5-FU by 24-h continuous s.c. infusion.
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Adrenal suppression is considered unusual where GCs have been prescribed for <2 weeks (18) but is more likely following prolonged administration (19).
Nevertheless, vigilance is recommended in the case of the prolonged administration (more than 10 years) of serotonin norepinephrine reuptake inhibitors (SNRIs), since for these recent products it has not yet been possible to study the associated long-term risks.
Paradoxically, because of more prolonged time and less intensive administration, the number of CMF cycles fared better among patients who received concomitant radiotherapy.
Intra-articular injection of hyaluronic acid (HA) or corticosteroids was also shown to improve pain, whereas the HA administration showed more prolonged effect [ 10, 11].
Each topotecan treatment cycle is composed of 5 days of administration and even more prolonged schedule has been considered (Hochster et al, 1999).
Rapid recovery of symptomatic plasma carnitine deficiency is obtained within 10 days by either oral high-dose treatment (3 4 g) in a single administration or by more prolonged therapy (Bizzi et al, 1978; Campos et al, 1993).
Even with the additional dose of protamine, the aPTT may remain more prolonged than would usually be found following administration of protamine to reverse unfractionated heparin.
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