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Patients with increased connectedness appear to have a more progressive disease course.
The recruitment of the patient participants from secondary care clinics rather than from primary care may have biased the sample towards those with more progressive disease.
However, focussing on the patient group, gamma values did significantly correlate with disease progression rate in patients with ALS, i.e. stronger interconnected motor networks show a more progressive disease course (Figure 4c).
Compared to late-onset dementia, it more often has an atypical presentation and more progressive disease course.
Our results generally suggest that an increased FN1 expression is correlated to a more progressive disease in RCC.
GLUT1-positive breast cancer cases not only displayed reduced Nuc-pYStat5 staining, but also represented more progressive disease, such as higher grade of cancer or lymph node metastases.
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Since avascular areas have also been reported in more progressive diseases, these areas have a prognostic value [ 38].
Towards the end of the period covered by this cohort, we began to treat more rapidly progressive disease more using higher administered activities, decreased intervals between cycles, or additional induction LuTate cycles.
Alternatively, the marimastat benefit may be related to the fact that this sub-group excludes those patients with more advanced or more rapidly progressive disease.
This influence is in line with studies that investigated risk-factor patterns that are associated with more progressive gastric disease [ 42].
Therefore, enhanced activation of necroptosis could serve as an indicator for more progressive liver disease, which should be evaluated in future prospective studies.
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