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Inclusion of the PSA0 level was considered plausible, as PSA is widely accepted as the marker for disease progression, and patients with more progressed disease can be expected to show inferior survival benefit.
In fact, during the CA/CD cross-validation experiments (a potentially more progressed state of oxidation) the artificially light aged fibre samples occasionally appeared as outliers.
When compared to the historic fibre removed from a sample area in poor condition, this peak is mainly dominated by the presence of CA indicating full conversion towards this product and a more progressed state of oxidation [12].
Regarding in vivo small intestinal motility, the peak distribution of the Evans bleu dye (geometric centre) was more progressed in NBW piglets of 28 d of age (P=0.03) compared to the other groups indicating more propulsive strength.
At the age of 18 months, neurodegeneration due to αSYN overexpression is at a much more progressed stage, impairing motor activity drastically as shown in MSA mouse models overexpressing αSYN under control of oligodendroglial promoters [51], [52].
These data also indicate that caution must be taken in treating human SS with therapies targeting the ICAM-1/LFA-1 interaction, since it is likely that most patients are diagnosed and request treatment in a more progressed stage of the disease.
Similar(10)
"More progress," Woods said.
Much more progress is needed.
Here they may make more progress.
But more progress is needed.
So room for more progress.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com