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Exact(4)
A comparison with the proliferation group in Oncotype DX suggests that AP4 contains significantly more prognostic power than that group.
In ER-negative breast cancers, RRM2 showed more prognostic power than that in ER-positive breast cancers.
Gene expression scoring for ESR1 and ERBB2 has good agreement with the corresponding protein biomarkers (ER and HER2) and may have more prognostic power.
The development of variables with more prognostic power was a primary goal in the development of gene expression signatures for breast cancer outcome.
Similar(56)
However, the newly developed combined models did use training and testing sets and barely outperformed the aforementioned predictors, which suggests that not much more prognostic powers are to be had by including hundreds of signatures beyond the powers contained within a well developed individual signature when combined with the clinical variables.
All of these molecular signatures have provided fascinating new insights into cancer biology, and they have more prognostic and predictive power than conventional factors, but surprisingly they are only incrementally more powerful, and we are still far from realizing the dream of truly personalized medicine.
Recent studies, based primarily on newer high-throughput technologies, have demonstrated that IBCs are enormously diverse at the molecular level, which suggests that the assessment of multiple molecular features simultaneously may have more prognostic and predictive power than conventional features.
In those patients, the NT-pro-BNP level was more likely to have prognostic power.
The appeal of such positive signatures is obvious, but there are many similar and all claim more or less the same prognostic power.
The superior diagnostic and prognostic power of [F]FDG-PET translates to more cost-effective lymphoma management as assessed in the UK health care system.
Furthermore, evaluation of the prognostic power of this gene on external microarray data (more than one thousand) confirmed the robustness of this marker at the RNA level (Jézéquel et al, 2008).
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