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"This is the next and the more profound stage of the battle for civil rights.
Therefore, if disease progresses into the more profound stage with BACE1 elevation, deleting a single BACE1 allele is not sufficient to block the BACE1-elevating mechanisms.
In conclusion, the results presented here demonstrate that the same degree of β-secretase suppression (e.g., 50% by BACE1+/− deletion) becomes less efficacious and eventually ineffective in reducing Aβ/C99 accumulation and rescuing cholinergic neurodegeneration or memory deficits in 5XFAD mice as disease progresses into the more profound stage that is accompanied by BACE1 upregulation.
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He was a Colin Kaepernick of his time, only on a more profound world stage and with greater implications.
He knew from the moment it started this was tragedy more profound than the stage.
The predatory state, the extreme insecurity, the sheer weakness of the rule of law these are problems more profound, at this stage, than a traditional left-right analysis can clarify, let alone begin to solve.
Atoh1 expression was more profound in later stages and was found in a cluster of cells in the remaining ganglia next to the utricle and saccule, mostly around the ectopic vesicles (Fig. 2E–G').
Quantification of mRNA revealed that most genes were transcriptionally down-regulated during the pathogenesis of vertebral fusions and that the suppression was more profound at the intermediate stage than in fused specimens.
Since the source materials used for viral small RNA analysis in this study were sampled at an early infection stage, a more profound perturbation of host gene expression may be detected at a later stage when viral siRNAs accumulate to a much higher level.
Can we imagine anticipating any changes more profound for the coming stages of our lives?
Sporting events, those scriptless dramas, often provide greater suspense and more profound human insight than the stage does.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com