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This may result in a more profound allele-specific effect on spliceosome assembly during transcription of the H2 allele, giving rise to the large increase in 4R-tau mRNA that we observe in Huntington's disease, especially given that SRSF6 is involved in MAPT exon 10 splicing (Yin et al., 2012) and co-localizes with mutant HTT inclusions (Fernández-Nogales et al., 2014).
A reasonable explanation for the present findings might be a more profound reduction in specific fat depots, such as visceral fat and liver fat.
To provide more profound and histotype specific survival data we have additionally performed a validation analysis in a validation set of 86 EOC with only serous histology.
It also reflects more profound information on the specific issues facing athletics at the international and domestic levels.
This is also logical diffuse patterns of inflammation that are likely to reflect a more profound physiologic alteration than a more specific inflammatory response.
More profound differences may originate from a subset of genes that displayed more distinctive prominence-specific expression patterns (Figures 13D).
Or more profound?
The impact is more profound.
Others want to make more profound changes.
Einstein, however, realized something more profound.
Probably more profound, too.
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