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The interferon-σ-encoding virus demonstrated greater activation of dendritic cells and drove a more profound secretion of proinflammatory cytokines compared to the parental virus.
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CONCLUSIONS Compared with youth with NGT, obese adolescents with IGT have evidence of a β-cell defect manifested in impaired first-phase insulin secretion, with a more profound defect in type 2 diabetes involving both first- and second-phase insulin.
Compared with wild-type mice, Akt1-/; Akt2+/- mice displayed a nine-fold reduction in oxytocin-stimulated milk secretion (P = 0.0001), a reduction even more profound than the four-fold reduction observed in Akt1-/; Akt2+/+ mice.
In contrast, in both model systems, glucose-triggered secretion was significantly reduced when SGLTs were inhibited by phloridzin, with more profound effects evident in the primary cultures (Fig. 5 a,b).
Or more profound?
The impact is more profound.
Others want to make more profound changes.
Einstein, however, realized something more profound.
But the current trend is more profound.
This sense is even more profound today.
Or is it something much more profound?
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