A more profound modification is to collapse the retina into a tiny blob of pigmented receptors and lead light from the very distant corneal facets to it via biological fiber optics.
The tool palette for aptamer synthesis includes not only natural DNA and RNA nucleoside monophosphates, but also non-natural building blocks with modifications at the 2′ position, such as 2′- O-methyl, 2′-fluoro-, and 2′- F-ANA; more profound sugar modifications, such as locked nucleic acid (LNA) and hexitol nucleic acid (HNA); or backbone modifications, such as phosphorodithioate linkages.
The next generation of polymer conjugation technology enables more complex and profound modification of cytokine activity.
Or is the change more profound?
Although verbal stimuli may more closely match the abstract ruminative processing style characteristic of depression (17), visual face stimuli are thought to elicit a more profound emotional response (18) and therefore may result in a greater bias modification effect.
However, further analyses of data suggest that the ancestral/innate compartment of immune system (e.g., MCs, NKs, DCs, MΦs) is relatively preserved in older individuals compared with the more acquired sophisticated and complicated adaptive immune cells (e.g., T and B cells, Treg, Th1/Th2, CD4+/CD8+) that undergo profound modifications throughout life [4, 6, 11, 13 15, 23, 58 61, 66 72].
The impact is more profound.
Others want to make more profound changes.
Einstein, however, realized something more profound.
