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These combinations also have more profound effects on cancer cell lines expressing wild type K- ras than those expressing mutant K- ras (Gulhati et al, 2012).
For all doses of NQO, methyl methane sulphonate and cisplatin wrn cells (solid lines) exhibited a more profound inability to maintain replication fork progression on a damaged template compared with wild type (dashed lines), in agreement with the recent work on human cells [24].
More profound differences were detected in carcinoma lines (Fig. 1A and not shown).
In the context of this ad, which focuses on these incredible children with disabilities, the line is even more profound.
The contrived controversy over President Obama's "you didn't build that" line raises a more profound question about his leadership that has been overlooked.
Both alleles were able to partially, but consistently, suppress the mutant AR-mediated rough eye phenotypes, although the nmo adk2 line showed a more profound rescue than nmo adk1.
"Nothing is funnier than unhappiness," Nell says, a mordant line that is made more profound by the baggage that Stritch brings onstage with her.
However, wortmannin displayed a more profound growth inhibitory effect on anti-estrogen-resistant cell lines than on parental MCF-7 cells.
Each change is more profound than the addition of a more complex story line or an enhancement to the graphics might be.
As expected, NRG1-induced pAKT S473) in both low HER2 and HER2 overexpressing MCF7 cancer cell lines, and the response in MCF7-HER2 was more profound (Fig. 5b).
The obtained data enabled us to conclude that HL1 had earlier and more profound toxic effect as compared to HL2 regardless of leukemic cell lines.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com