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When myostatin is genetically deleted or inhibited by transgenic expression of the myostatin binding protein follistatin, there is a more profound increase in muscle mass and both hypertrophy and hyperplasia of fibers is observed [4], [5].
However, in accordance with previous studies, high concentrations of NMDA and glycine as well as specific activation of extrasynaptic NMDA-receptors resembling pathological conditions induce an even more profound increase of nuclear Jacob levels.
Irradiated cells showed a moderate increase in WEE1 expression and a more profound increase in expression of CDC2 -pY15 compared to untreated cells.
Hence, the more profound increase in atopy with age in the urban site could be attributed to the higher mean age of the urban participants in this study.
Interestingly, after treatment with ERA-63, a more profound increase in uterus weight was observed in ERβ-/ mice when compared with wild type mice.
In this procedure a Gore-Tex interposition shunt graft is used to anastomose the ascending aorta to the main pulmonary artery for a more profound increase in the pulmonary circulation (Fig. 2) [ 5].
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If only those castrated earlier in life were considered, the effect on lifespan was more profound: an increase in median lifespan of 11.6 years.
Joint hypermobility has been known for centuries, but not until recently has it attracted a more profound and increasing scientific interest.
S/S compared with L/L subjects reported greater examination stress, and this was accompanied by a more profound post-stress increase in appetite for sweet snacks.
More specifically, we observed darker areas around the pores, which became more profound with the increase of the electron energy, meaning that the yield of the back-scattered electrons for these areas decreases.
An infusion of kisspeptin-10 for 11 h at a higher dose (4 µg/kg/h (3.1 nmol/kg/h)) produced a more profound 5-fold increase in LH release (George et al., 2013), also comparable to the response in healthy men (George et al., 2011).
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